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Additional details on qualitative outcomes in ALS can be found elsewhere [62]

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These interactions, including hydrogen bonds and hydrophobic interactions, contribute to their inhibitory activities against the respective enzymes

Notable trials include the combination of Enfortumab vedotin with ICIs in urothelial cancer, which has shown significant improvements in OS and PFS compared to traditional chemotherapy [205, 436, 437]

Increased expression of UCP3 is associated with increased oxygen use and reduced cardiac efficiency in dietary models of obesity.48 The detrimental processes activated by mitochondrial dysfunction occur in addition to damage by lipotoxic products from the accumulation of triglycerides