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Author contributions WA: Data curation, Formal Analysis, Investigation, Methodology, Project administration, Software, Supervision, Validation, Visualization, Writing original draft, Writing review & editing

The authors confirmed that AngIV analogs can inhibit HGF binding to c-Met and HGF-dependent signaling by interfering with HGF dimerization, a crucial step for c-Met activation

This makes morphine and codeine candidate immunosuppressant adjuvants for regulating the cytokine storm observed in COVID-19 (Roshanravan et al., 2020b)