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doi: 10.1016/j.vetimm.2014.08.007 41 MnsterP.VlkelI.WemheuerW.SchwarzD.DringS.CzernyC

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Furthermore, although an alum-adjuvanted double-inactivated SARS-CoV vaccine elicited higher antibody titres in aged mice, it skewed the IgG subclass toward IgG1 instead of IgG2, which was associated with a T helper 2 (T H 2)-type immune response, enhanced eosinophilia and lung pathology 13