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Tiny cells known as osteoclasts and osteoblasts digest old bones while simultaneously laying down new, healthy bone in its place [4]

Read together with the failed fosgonimeton trial, the takeaway is that the human-relevant evidence base for this class is both thin and, where it touched humans, negative

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Hopx was involved in early developmental and differentiation pathways 32

The factor was operationally defined by its EEG signature long before its chemical identity was known