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Ghaffari, 2022)

28 Male fertility The MTHFR C677T mutation has been associated with lower sperm counts and increased male infertility

TXNIP co-localizes with and reduces the activity of TRX in Jurkat T cells treated with the tumour-suppressor lipid ceramide, leading to dissociation of TRX from apoptosis signal-regulating kinase-1, ER stress, phosphorylation of p38 and JNK, and subsequent cellular apoptosis 20