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Enhanced Mitochondrial Function Mitochondrial dysfunction is a critical factor in NAFLD progression

has identified death of intestinal epithelial cells via necroptosis as a critical mechanism of intestinal barrier disruption during the onset of CIA [1]

Ohayon, M

Additionally, MSU crystals diminish intracellular NAD+ concentration by stimulating the nicotinamide adenine dinucleotide (NAD+) degrading enzyme (CD38) in macrophages, subsequently promoting IL-1 secretion (41)