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It is interesting to note that immune cells like microglia and macrophages shift from oxidative phosphorylation (typical of M2 type phenotype), which corresponds to an inactive state, to aerobic glycolysis (typical of M1 type phenotype), which corresponds to a proinflammatory state [41,42]

The eosinophilia was gradually replaced by neutrophilia in adult mice, while eotaxin-1 levels decreased and GRO- levels increased, examination of DCs activation revealed increased DCs activation in the lungs of SLC7A2-deficient mice (131)

The activation of downstream effectors, including HO-1, NQO1, and -GCS, was facilitated by the effect of H 2 O 2 exposure on oxidative molecules, which stimulated Nrf2 signaling

From a clinical perspective, functional imaging of hypoxia, redox imbalance, and acidosis is increasingly being explored as part of a precision oncology framework

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