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mtDNA from hepatocytes released into circulation promote inflammation through binding to endosomal TLR9 of liver resident Kupffer cells ( 6 in Figure 1) ( Non-alcoholic fatty liver disease is a vivid example of how systemic immune responses are regulated by metabolism, and that harmful local fibrosis of the liver can develop if these systemic metabolic disturbances remain unresolved

Hoekstra M

A scaling factor greater than one indicates that the model fingerprint needs to be scaled up to best match the observations (i.e., the model underestimates the magnitude of the trend), and a scaling factor less than one means that the model fingerprint needs to be scaled down to best match the observations

This defect can be genetic, meaning people with parents or family members who have experienced oxalate dumping have a higher risk of also experiencing oxalate dumping

The tritium water content was 30.1% (female) and 29.3% (male), and the content of [ 3 H]proline (M1) was higher, accounting for 20.7% (female) and 30.2% (male) of the total radioactivity (Figure 5D)