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Although the exact mechanism of how coffee enemas cause proctocolitis is not known, it is suspected that the proctocolitis is caused by the chemicals in coffee enemas, as coffee is a complex mixture of chemical compounds that contain more than just caffeine

Further more, oxidized DNA is more resistant to degradation by cytosolic nucleases (Gehrke et al., 2013), therefore oxidants can promote the accumulation of DNA in the cytosol, and potentiate the activation of the cGAS-STING pathway (Gehrke et al., 2013)

Only isovalerate concentration in the colonic digesta increased significantly in response to Dex ( p 0.05) (Table 2)

Four replicates from each group were analyzed independently for library synthesis and sequencing

IJET 7:788793 Baca-Lopez K, Fresno C, Espinal-Enriquez J, Martinez-Garcia M, Camacho-Lopez MA et al (2021) Spatio-temporal representativeness of air quality monitoring stations in Mexico City: implications for public health