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Analysis of these proteins by DSC revealed that the folded structures are located entirely within these peptides, whereas a thermorgram of the C-terminal domain of H1 contains no peak and shows high C p values, thereby indicating that this domain is not folded (Crane-Robinson and Privalov, 1983)

2 Early symptoms may include gastrointestinal disturbances such as nausea, vomiting, and abdominal pain, which may progress to more severe manifestations, including jaundice, hepatic encephalopathy, and coagulopathy in patients with advanced liver injury

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Valavanidis, A., Vlachogianni, T