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10.1371/journal.pone.0232238 6

Potential solutions for this issue include generating artificially-aged neurons through the direct lineage conversion of patient fibroblasts to create induced neurons (iNs) [92, 93], or actively stimulating the rapid ageing of iPSC-derived models via progerin exposure [94]

Because NACET is lipophilic (fat and water soluble) it does not pool in the stomach and is not hoarded by other cells

A further series of in vivo experiments to evaluate immunocompatibility included a c(RGDyK)-modified liposome (RGD-Lip) as a positive control (Supplementary Fig