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J Adv Pharm Res 2023;7(1):1-14

The result is a sustained decline in sex steroid hormones, a state sometimes described medically as chemical castration in men or hypogonadism in both sexes

Compared to humans and mice, rats have a higher basal level of antioxidant defense gene expression, and rats have a greater capacity to respond to cellular stress, which makes them generally more resistant to drug toxicity [127]