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Strategies devised to reduce/eliminate glucose-associated toxicity (glucose sparing), represent one of the key objectives of present-day research in PD

A role for DNA methylation in the dysfunction of oligodendrocytes and myelin in neurodegenerative diseases Epigenetic modifications are those which, without altering the underlying DNA sequence, bring around changes in gene expression

IL-1-dependent enteric gliosis guides intestinal inflammation and dysmotility and modulates macrophage function

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In the GST family, early studies demonstrated that the GSTP1 gene plays an important role in several cellular processes, including catalysis and deoxylation of electrophilic compounds, oxidative stress regulation, cell signaling and carcinogenesis (25,26)