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A GPR56-targeted antibody-drug conjugate (ADC) in preclinical study utilizing duocarmycin SA, a DNA minor-groove alkylating agent, demonstrated target-dependent tumor growth inhibition in CRC xenografts and patient-derived organoids with acceptable tolerability (90, 93)

Trying to understand if 3D cerebral organoids can replicate the disruption observed in 2D cultures, Inak et al

A neurotransmitter produced by gut bacteria modulates host sensory behaviour

Dectin-1: a signalling non-TLR pattern-recognition receptor

The scientific basis for peptides in promoting muscle growth lies in their ability to directly affect muscle at the molecular level, often targeting receptors on cells or increasing hormonal levels, says Major Brandon Roberts, Ph.D., C.S.C.S