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Diallyl trisulfide prevents adipogenesis and lipogenesis by regulating the transcriptional activation function of KLF15 on PPAR to ameliorate obesity

The importance of zinc homeostasis is highlighted by the remarkable number of diseases associated with alterations in tissue zinc levels, which is summarized in Figure 1 (right hand side)

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359 Shikonins dual inhibition of TRXR and PKM2 induces necroptosis, whereas Nrf2 hyperactivation mediates resistance, which can be reversed through metabolic targeting

Therefore, the GPx-like catalytic activity of compounds was studied using glutathione (GSH) as thiol cofactor and hydrogen peroxide (H 2 O 2 ) as substrate [57, 58]