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Figure 2 3.3 Antioxidant defense Lipid peroxidation can be countered by antioxidant systems, in which the cystine/glutamate-GSH-GPX4 is the main antioxidant pathway (29)

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Virus was injected (70 nL at 35 nL/min at 200 m depth from the brains surface) at three evenly spaced locations positioned to stay clear of large blood vessels, and a glass plug consisting of two coverslips glued together were placed in the craniotomy, slightly pressing the dura to prevent dural overgrowth (Bojarskaite et al

FIGURE 3 Malondialdehyde is produced in vivo through both enzymatic and non-enzymatic oxidation, making it a widely monitored biomarker for oxidative stress across various diseases and particularly favored for characterizing oxidative stress in AD patients (57)