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Mitochondria are therefore particularly affected by oxidative attack throughout life

S.MusialN.et al (2019)

Graf, C., Elmassry, M., Chu, V

Urol Clin North Am 2007

Yet, immediate-release nicotinic acid is often used at higher doses than extended-release forms, and severe liver toxicity has occurred in individuals who substituted extended-release nicotinic acid for immediate-release nicotinic acid at equivalent doses (126)