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In summary, we have shown that Tg-I278T Cbs / mice lacking CBS activity have decreased serum tCys, decreased liver GSH, decreased fat mass, facial alopecia, reduced bone mineral density and more than 90% reduction in liver Scd-1 mRNA compared to sibling control animals

Comprehensive exercise achieves maximal effects by combining moderate-to-high intensity aerobic loads with explicit cognitive tasks, thereby activating neurotrophic factor pathways (e.g., the BDNF pathway) and the prefrontal executive function network (Longfei et al., 2025

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