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The complexity of signaling pathways and systemic effects often obscures the precise mechanisms and causal relations

DNA Damage response signaling pathways and targets for radiotherapy sensitization in cancer

Pb 2+ also activates the synthesis and secretion of the proinflammatory cytokine IL-8 through a nuclear factor erythroid 2-related factor 2 (Nrf2)-dependent mechanism involved in the synthesis of xenobiotic-metabolizing enzymes (Metryka et al

doi: 10.2147/vhrm.s1991