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HIF-1 accumulation was further shown to be dependent on the mammalian target of rapamycin (mTOR) kinase [76], a central regulator of myeloid cell growth and metabolism, which was recently shown to play a vital role in the ability of MCs to re-granulate following activation [77]

Part of the data has been used in previous publications that have not focused on age-related effects on mitochondrial respiration 24,25,26,27,28,29,30

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Supplementation: Oral glutathione 500 mg daily, in addition to polypodium extract 480 mg twice a day

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