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31 However, despite promising results from preclinical studies, including the targeting of mast cells through inhibition of the c-Kit RTK, 32 when inhibitors targeting various relevant RTKs were tested in clinical trials using sorafenib for patients with OPG 33 (NCT01338857) or imatinib for pNF 34 (NCT01673009) and MPNST 35 (NCT00031915), disappointingly, they largely lacked efficacy at reducing tumour burden