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The application of these nanomedicines can improve the membrane permeability and stability of STING agonists, facilitate lysosomal escape, and enable targeted and controlled release of STING agonists

As the added H 2 O 2 is eliminated rapidly by pyruvate in these media, 50% in 5 min and 95% in 25 min, caution must be taken in the interpretation of the results, especially when comparing different studies

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In univariable, time-dependent Cox models, the optimal MAP cutoff most associated with AKI reversal was 84mmHg ( p =0.005) (Figure 1)