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Additional data demonstrated that the HLA molecules DQA1*0501, DRB1*0301, DQB1*0202, DQB1*0603, DQB1*0609, DQB1*0302, DQB1*0303 were also closely associated with higher risk of developing GD (124-128)

Indeed, the pediatric autoimmune neuropsychiatric disorder associated with group A -hemolytic streptococcus (GABHS) (PANDAS) and thus the recalled pediatric acute neuropsychiatric syndrome (PANS) have highlighted that several agents rather than streptococcus could be involved in these acute-onset forms of OCD 48

Seib CD, Sosa JA

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