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Cadmium and arsenic can sustain estrogenic signaling and activate MAPK/ERK and PI3K/Akt pathways even under tamoxifen treatment, while arsenic-mediated BRCA1 methylation further reduces drug responsiveness

It occurs during numerous pathological processes and causes anaemia, one of the most frequent side effects of cancer chemotherapy

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Zhu et al., Reference Zhu, Boulet, Buckley, Phillips, Gammon, Oldfather, Moore, Leary and Cobine2021)

Finally, a recent review by Dayan (2025) demonstrates the need to balance the psychological and ethical considerations in aesthetic medicine, distinguishing between objective beauty and subjective attractiveness while emphasizing the importance of a patients self-confidence in ethical practice [86]