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164 In addition, some nonselective or selective agents against NLRP3 inflammasome including melatonin (NCT04409522), OLT1177 (NCT04540120), aai palm berry extract ( Euterpe oleracea ) (NCT04404218), and ZYIL1 (selective inhibitor) (NCT04731324) are under investigation

Cellular and Molecular Life Sciences

Mutations in ironsulfur cluster scaffold genes NFU1 and BOLA3 cause a fatal deficiency of multiple respiratory chain and 2-oxoacid dehydrogenase enzymes

Lab guides emphasize evaluating the clinical picture and, if levels are unexpectedly high, considering follow-up with repeat testing, a complete blood count, and liver/kidney panels ( vitamin B12 and folate test overview )