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In another study, abnormal methylation was found within the gene promoters related to imprinting, spermatogenesis as well as defense system of antioxidant sort in the sperm of patients having impaired sperm DNA integrity status (Reference Song, Wang and Chen23)

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Overall, approximately 68% of patients receiving chemotherapy develop CIPN within the first month of treatment (Seretny et al., 2014), the development of which is related to both single as well as cumulative drug doses