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Treatment effects, period effects and treatment-period interaction were analyzed using a 2-sample t-test

Genetic associations with CVD and its risk factors The data sources of all outcomes are shown in Additional file 1: Table S1

1 CLD is a broad term encompassing various liver disorders, including alcoholic liver disease (ALD), non-alcoholic fatty liver disease (NAFLD), viral hepatitis, drug-induced liver injury (DILI), hepatic fibrosis (HF), and hepatocellular carcinoma (HCC)

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In another double-blinded clinical study [47], 36 patients presenting MS-related fatigue randomly received ALC at a dose of 1g twice daily or amantadine at a dose of 100 mg twice daily for a period of 3 months