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these include inhibition of activation of the PI3K/Akt-mediated Nuclear Factor kappa-B (NF-B) and MAPK signaling pathways, as well as the promotion of regulatory T cell (Treg) function and enhancement of alveolar epithelial sodium channel (ENaC) activity (alleviating inflammation and oxidative stress responses)

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GS then catalyzes the second step, consuming another molecule of ATP to add glycine to -Glu-Cys, ultimately forming GSH