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Similarly, in ex situ organ perfusion (ESOP) (60), the absence of the biological role of organs, such as the liver, leads to the inability to scavenge oxygen radicals generated by oxidative stress, thus making such a technique more challenging compared with physiological conditions ( 4.3 Endogenous and exogenous coagulation systems Under normal physiological conditions, coagulation mechanisms include both coagulation and anticoagulation, and the dynamic balance between them plays a key role in maintaining normal blood flow and preventing coagulation (61)

Int J Environ Res Public Health 17(12):4385 Chen X, Zhu G, Wang Z, Zhou H, He P, Liu Y, Jin T (2019) The association between lead and cadmium co-exposure and renal dysfunction