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The MHRA has not issued specific warnings about B12 toxicity from supplements, reflecting the vitamin's excellent safety profile in the general population

[DOI] [PubMed] [Google Scholar] Johri A., Chandra A., Flint Beal M

Since cortisol secretion also follows a regular circadian pattern roughly opposite to that of melatonin, this finding provides additional confirmation of possible day-night cycle disturbance in women with PCOS