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CM has been shown to alter the hypothalamicpituitaryadrenal (HPA) axis response to stress, leading to modified DNA methylation of the glucocorticoid receptor ( NR3C1 ) and BDNF genes, which in turn increases susceptibility to schizophrenia (Barker et al., 2020

In constructing IVs 14 , we screened single nucleotides with a P value less than 5 10 8 , as specified by the European 1000 Genomes Project, and located within 10,000 kb of the transcription start site (TSS) of each genes polymorphism (SNP)

CBS is predominantly found in the brain, kidney, and liver

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1-Methyl-4-phenylpyridinium (MPP+, Sigma-Aldrich, USA, D048) was dissolved in dimethyl sulfoxide (DMSO, Sigma-Aldrich, USA, D2650) to a final concentration of 0.01%