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These findings are associated with increased transcriptomic expression of pro-inflammatory cytokines, tissue repair molecules and markers of oxidative stress in the myocardium

High concentrations of ROS in the ER lumen may also subsequently activate the ER calcium release channel type 1 inositol 1,4,5-trisphosphate receptor (IP3R1), leading to the leakage of calcium from the ER lumen into the cytoplasm

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Furthermore, diverse methods employed in animal models and drug administrations pose challenges when comparing therapies efficacy

Local and systemic recurrences have a poor prognosis and early detection of the disease might not influence survival [462]