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The authors further note that HTP aerosol temperatures can still reach levels sufficient for nicotine pyrolysis, potentially eliciting similar oxidative responses to those from combustible cigarettes

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Retention times and MRM transitions for nicotine and its metabolites are presented in Table 1

As this 2015 review summed up: Studies deploying a range of methodologies, including observational and experimental research, consistently show that plain packaging can reduce the appeal of cigarettes, decrease the power of the cigarette pack as a marketing vehicle, increase attention to the health warning labels, and impact smoking-related attitudes and cognition