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They refer to this ratio as the 'margin of exposure' (MOE), which can be used to measure how likely a user is, on average, to unwittingly overdose on their drug of choice

The PBMCs were aliquoted (50 l/well) into 96-well flat-bottom tissue culture plates pre-coated or not as above with 0.5 g/mL of anti-human CD3 and then 2 g/mL anti-human CD28 added