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In contrast, Huayan 06 significantly reduced after 8h treatment, but the decrease was smaller than that of K326 ( Figure 8B )

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This may seem insignificant, but if you consider that cardiac output can vary anywhere from 20%-50% while exercising, adding the effect of smoking to that is likely to 1) prematurely tire the heart muscle(s) and 2) increase the likelihood of a heart attack during exercise