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Briefly, the mean (Mean HC ) and standard deviation (SD HC ) of each DMP associated with type I and/or type II IFN-regulated genes or genes involved in TNF/IL-17 pathways were calculated using the healthy control group

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Figure 2 2.1.1 Effects on innate immune system Neutrophils are the most abundant leukocytes population in peripheral blood, and they exert their activity early during inflammation, releasing cytokines, proteases, producing reactive oxygen species (ROS), and creating neutrophils extracellular traps (NETs) ( Alpha-1-antitrypsin (A1AT), beyond its role as a serine protease inhibitor, exhibits significant antioxidative properties, playing a crucial role in the neutralization of reactive oxygen species (ROS) through sophisticated mechanisms

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doi: 10.1194/jlr.M010264 132