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Covariates Covariates were selected a priori as plausible confounders of the association between the exposure and hypertension prevalence [9,10,11, 27]

Conclusion: This study, integrating bioinformatics and MR analysis, identified three potential predictive targets as mediators to investigate the causal relationships between different smoking statuses and NSCLC through potential therapeutic targets, providing new insights for the treatment and prevention of NSCLC