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Description

Demethylase activity is directed by histone acetylation

Their poor cartilage specificity and rapid clearance from the joint cavity further limit therapeutic durability

Interventions included oral GABA (1 gram/M2/day up to a maximum of 1.5 gram/day or approximately 30 mg/kg/day, see Figure 2 ) divided into two daily doses with or without two GAD-alum injections (20 mcg/dose)-one at baseline and the other at one month