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These geographic factors illustrate the complexities in a chronic disease entity like IBD, with a multifactorial etiopathogenesis and multiple, relatively weak predictive associations of disease prognosis, in assessing whether a variable such as smoking status truly has an independent, significant impact on disease course and/or treatment outcomes

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This development of the female market occurred in tandem with an expansion of the "luxury cigarette" concept aimed at men and women, through the appearance of "luxury, opulence and sophistication" of packaging

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