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(S)-(-)-Cotinine, the major brain metabolite of nicotine, stimulates nicotinic receptors to evoke [3H]dopamine release from rat striatal slices in a calcium-dependent manner

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A randomized phase I comparative pharmacokinetic study comparing SB5 with reference adalimumab in healthy volunteers

In humans, more than 70% of nicotine is transformed to cotinine, which is subsequently converted to trans -3-hydroxycotinine, the main nicotine metabolite detected in urine [2]