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Studies treating mild to moderate B12 deficiency in older people have failed to provide cognitive benefits: A clinical trial from the Netherlands measured the cognitive response to B12 supplements in people 70 years old with mild B12 deficiency and MMA levels 320 nmol/l (average: ~450 nmol/l)

Additionally, the effectiveness of teaching and spreading information to adolescents about the dangers of e-cigarettes through social media campaigns and other marketing programs, such as sponsoring music festivals, needs to be measured in order to understand the long-term impact of these campaigns