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Figure 2 Oral potentially malignant disorders associated with smoking (only smokers + smokers who also chew tobacco) and chewing (only chewers + chewers who also smoke) forms of tobacco Figure 3 Oral potentially malignant disorders associated with smoking and chewing forms of tobacco with no mixed usage Meta-analysis of studies evaluating oral malignancy associated with tobacco smokers and chewers for mixed (overall) and no mixed usage are presented in Figures 4 and 5

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P values were determined by Kolmogorov-Smirnov statistic with sample randomization

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Nonetheless, the company has come under fire from anti-smoking campaigners who accused it of hypocrisy after it launched a 1.2 billon takeover bid for Vectura, a British pharmacy company that makes asthma inhalers