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Dokoupil asked Calantzopoulos, "How, after years of acknowledged deception on the part of the tobacco industry, do you convince not only regulators but the public to trust you this time when you say [e-cigarettes are] better?" "Look, it's very nice to say, 'Philip Morris, you can't believe them today because you couldn't believe them yesterday,' and so on

But quitting smoking remains an awfully difficult challenge and novel approaches, either alone or in conjunction with existing interventions, are sorely needed, Sayette said by email

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If there are no disagreements, b and c would be zero, and the reviewers agreement (po) is 1, or 100%

And getting help from an NHS stop-smoking clinic leads to a four-fold rise in the chances of succeeding, according to Public Health England