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Increased frequency of constipation and delayed diagnosis and treatment increased the risk of severe complications of gastrointestinal hypomotility, which can result in fecal impaction, megacolon, and intestinal obstruction, ischemia, infarction, perforation, ulceration, or necrosis [see Adverse Reaction (6.2)]

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Paucigranulocytic asthma The final asthma phenotype is paucigranulocytic asthma (PGA), which is characterized by the absence of evidence of elevated eosinophil or neutrophil numbers in sputum or blood

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