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Hypothalamic-pituitary-adrenal (HPA) axis The fetal hypothalamic-pituitary-adrenal (HPA) axis is critical for mechanisms controlling the regulation of intrauterine homeostasis, the timely differentiation and maturation of vital organ systems such as the CNS, liver, and lungs, preparing the timing of fetal growth, and commencing parturition [37, 38]

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