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Nitrogen dioxide (NO2): This gas, often present in vehicle exhaust and industrial emissions, can cause a negative interference in some CO sensors, reducing their ability to detect CO accurately

Younger people are more prone to ear infections because the canal that's supposed to drain fluid and control pressure is too small

In the guidance for industry on PMTAs for ENDS, CTP documented that a data package might require the following, non-clinical investigations, if available ( FDA, 2019a ): In vitro toxicology studies (e.g., genotoxicity studies or cytotoxicity studies) Computational modeling of the toxicants in the product (to estimate the toxicity of the product) In vivo toxicology studies (to address unique toxicology issues that cannot be addressed by alternative approaches) Throughout this guidance document, CTP states its support for reducing, replacing, and/or refining the use of animal testing where adequate and scientifically valid NAMs can be substituted (FDA, 2019a)

Deep Breathing: Forces the deep, deliberate breathing that smokers use, which can actually be calming

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