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The studies analyzed consistently highlight adolescence as a critical period of neurobiological maturationparticularly within the prefrontal cortex and limbic regions that regulate cognition, emotion, and decision-makingduring which nicotine exposure may confer heightened vulnerability ( Nicotine acts on nicotinic acetylcholine receptors, affecting neurotransmission and synaptic plasticity

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"It was like a routine," the "Thinking Out Loud" singer told the host