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The tax differential is why cross-border cigarette purchasing (buying in low-tax states for use in high-tax states) is a persistent behavior despite being technically illegal for personal importation above personal-use quantities

Enforcement began on January 1, 2019

As a result, because there is no combustion involved in vaping, many adult smokers explore electronic cigarettes when looking for smoke-free alternatives to continued traditional cigarette smoking

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This highlights the importance of replicating these studies in both studies using human tissue (where possible) and clinical trials, as the mechanisms driving acute and/or chronic cough may be different