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While the results of epidemiological studies examining the effects of smoking on the development of EH are controversial (reviewed in Samadian et al., 2016), there are several lines of evidence supporting a causal relationship between smoking and EH: an in vivo mouse model provided convincing evidence that chronic cigarette smoking causes hypertension and cardiac remodeling (Talukder et al., 2011)

She struggled to quit but was eventually forced by her pregnancy

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