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Here are some of the factors that will affect how long it takes for marijuana to wear off: The bodys metabolism rate The time of day you choose to ingest the drug How often you use cannabis products (frequency) Whether other drugs were also consumed about the time of marijuana consumption The amount of marijuana taken at one time How the product was consumed The potency of the marijuana product Amount of individual body fat While multiple factors play a role in determining how your body will handle the effects of marijuana, we will look at some baseline estimates to help give you a better understanding based on various factors